17 Epistasis Models

Learning Objectives

By the end of this chapter, you will be able to:

Define additive×additive, additive×dominance, and dominance×dominance variance
Build epistatic relationship matrices as Hadamard products of A and D
Set up a model containing an epistatic term
Explain why epistatic variance is nearly unidentifiable from pedigree data
Justify the additive model used throughout the rest of the book

Assumes Ch 1 (§1.7), Ch 16.

Chapter in progress

This chapter has not been written yet. The objectives above are the contract it will be written against — they are taken from CHAPTERS.md, which is the outline for the whole book.

Purpose. Capstone to Part V, answering the question the whole book raises: why is everything else additive?

---
title: "Epistasis Models"
---

::: {.callout-note icon=false}
## Learning Objectives

By the end of this chapter, you will be able to:

1. **Define** additive×additive, additive×dominance, and dominance×dominance variance
2. **Build** epistatic relationship matrices as Hadamard products of **A** and **D**
3. **Set** up a model containing an epistatic term
4. **Explain** why epistatic variance is nearly unidentifiable from pedigree data
5. **Justify** the additive model used throughout the rest of the book
:::

*Assumes Ch 1 (§1.7), Ch 16.*

::: {.callout-warning}
## Chapter in progress

This chapter has not been written yet. The objectives above are the contract it will be written
against — they are taken from `CHAPTERS.md`, which is the outline for the whole book.

**Purpose.** Capstone to Part V, answering the question the whole book raises: why is everything else additive?
:::